Kinetics of Pertussis Immune Responses to Tetanus‐Diphtheria‐Acellular Pertussis Vaccine in Health Care Personnel: Implications for Outbreak Control

Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control.

We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.

Bordetella pertussis booster vaccination for health care personnel immediately following a pertussis outbreak in a hospital?

Pertussis, caused by the small gram-negative bacterium Bordetella pertussis, is a life-threatening disease in young infants. Although almost all mortalities occur in children aged !6 months, the bacterium causes significant morbidity in all age groups [1], and adolescents and adults are often the source of infection in small children. Symptoms may be the classic ones, with paroxysmal cough and ...

Immune responses to pertussis antigens in infants and toddlers after immunization with multicomponent acellular pertussis vaccine.

Given the resurgence of pertussis despite high rates of vaccination with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine, a better understanding of vaccine-induced immune responses to Bordetella pertussis is needed. We investigated the antibody, cell-mediated, and cytokine responses to B. pertussis antigens in children who received the primary vaccination series (at 2, 4, and 6 months...

Immune responses to pertussis vaccines and disease.

In this article we discuss the following: (1) acellular vaccines are immunogenic, but responses vary by vaccine; (2) pertussis antibody levels rapidly wane but promptly increase after vaccination; (3) whole-cell vaccines vary in immunogenicity and efficacy; (4) whole-cell vaccines and naturally occurring pertussis generate predominantly T-helper 1 (Th1) responses, whereas acellular vaccines gen...

Title : Immune Responses to Pertussis Antigens in Infants and Toddlers after 2 Immunization with Multicomponent Acellular Pertussis Vaccine